How patients use the prefilled syringe at home
UCB, Inc. and OXO Good Grips® have partnered to create a unique prefilled syringe designed with the needs of patients in mind.
Patients who are capable may self-inject CIMZIA using the prefilled syringe after proper training in subcutaneous injection and if an HCP determines that it is appropriate.
Patients using the CIMZIA prefilled syringe should be instructed to inject the full amount in the syringe, 200 mg (1 mL), according to the full injection instructions provided in the Instructions for Use booklet found in each CIMZIA prefilled syringe kit.1
Prefilled syringe designed with patients in mind2


OXO, Good Grips® and the associated logos are registered trademarks of Helen of Troy Limited and are used under license.
Preparing and administering CIMZIA using the prefilled syringe

Importance of training
Patients should not give themselves a CIMZIA injection unless they have been shown how by an HCP, nurse, or someone who has been trained to help them with their injections. The following instructions describe the steps your patients need to follow to inject CIMZIA.
Instructions for Use for your patients
CIMZIA solution for subcutaneous use prefilled syringes
Patients should watch the following video and/or read the following instructions before receiving or injecting CIMZIA. Patients should reread these instructions before every self-injection of CIMZIA. These instructions do not take the place of talking with a healthcare professional about a medical condition or treatment. These instructions are for 1 injection only. Your patient may need more than 1 injection at a time depending on the prescribed dose of CIMZIA.
Please instruct your patients not to share a CIMZIA prefilled syringe with another person, as doing so may give another person an infection or give your patient an infection.
Supplies your patients will need:
- 1 CIMZIA prefilled syringe with needle attached. Your patient may need 2 CIMZIA prefilled syringes with needles attached to give higher doses
- 1 or 2 alcohol swabs
- 1 or 2 clean cotton balls or gauze pads
- 1 puncture-resistant sharps disposal container. See “Disposing of the Syringe” at the end of these instructions
CIMZIA comes in a tray containing 2 prefilled glass syringes. Your patient should use a new CIMZIA syringe for each injection.
Preparing to take CIMZIA:
Step 1: Your patient should take the carton containing the prefilled syringes of CIMZIA out of the refrigerator. Your patient should check the expiration date on the syringe carton and label.
If the expiration date has passed, your patient must not use the syringe. Your patient should call a pharmacist if they have questions about the expiration date. Your patient must not use CIMZIA if the tamper evident seals are missing or broken on the top or bottom of the carton when your patient receives it. If the tamper evident seals are missing or broken, your patient should contact a pharmacist.
Step 2: Your patient should remove the prefilled syringe from the carton and let it warm to room temperature. Your patient must not warm the syringe in any other way. If your patient is not using the second syringe, the carton containing the remaining prefilled syringe should be put back in the refrigerator.
Step 3: Your patient should find a clean, flat work surface, such as a table.
Step 4: Your patient must make sure the liquid medicine in the prefilled syringe is clear and colorless to yellow and free from particles. Your patient must not inject the medicine if it is cloudy, discolored, or contains particles. Your patient should call a healthcare professional or pharmacist if they have any questions about the CIMZIA prefilled syringe.
Step 5: Your patient should gather all the supplies needed for injection.
Step 6: Your patient should wash hands with soap and warm water and dry with a clean towel.
Injection site preparation:
Step 7: Your patient should choose an injection site(s) on the stomach or upper thighs.
- Your patient should choose a new injection site each time CIMZIA is used
- Each new injection should be given at least 1 inch from the site used before. If your patient chooses the stomach site, they should avoid the 2 inches around the belly button (navel)
- Your patient must not inject into areas where skin is tender, bruised, red or hard, or where scars or stretch marks are present
- Your patient should change injection sites between the stomach and upper thighs to reduce the chance of having a skin reaction
- Your patient may want to write down the site used for each injection to help them remember to use a different site with each injection
Step 8: Your patient should clean the injection site with an alcohol swab. Let the area dry completely.
Injecting CIMZIA:
Step 9: Your patient should pick up the prefilled syringe with 1 hand and hold it with the needle pointing up. Your patient may see air bubbles. This is normal. There is no need to remove air bubbles before they complete the injection. Injecting the solution with air bubbles will not harm your patient. With the other hand, your patient should remove the plastic ring needle cover by pulling straight up on the plastic ring. Your patient must not touch the needle and must not let the needle touch any surface. Your patient must not bend the needle. Your patient should place the plastic ring needle cover to the side.
Step 10: With the other hand, your patient should gently pinch a fold of skin at the cleaned injection site.
Step 11: With a quick, dart-like motion, your patient should insert the needle into the skin at about a 45-degree angle. Your patient should release the pinched skin, keeping the syringe in position. Your patient should slowly push the plunger all the way down until the syringe is empty.
Step 12: When the syringe is empty, your patient should pull the needle out of the skin while carefully keeping the needle at the same angle as inserted.
Step 13: Your patient should place a dry cotton ball or gauze pad over the injection site for several seconds.
Your patient must not rub the injection site. Your patient must not use an alcohol swab as it may cause stinging. If there is a little bleeding, your patient should cover the injection site with a small bandage.
To avoid a needle-stick injury, your patient must not try to recap the needle. Your patient must not reuse any injection supplies.
Disposing of the syringe:
Your patient should put used syringes with needle attached in an FDA-cleared sharps disposal container right away after use.
Your patient should not throw away (dispose of) loose syringes and needles in household trash.
- If your patient does not have an FDA-cleared sharps disposal container, your patient may use a household container that is:
- - Made of a heavy-duty plastic
- - Can be closed with a tight-fitting, puncture-resistant lid without sharps being able to come out
- - Upright and stable during use
- - Leak-resistant
- - Properly labeled to warn of hazardous waste inside the container
- When your patient’s sharps disposal container is almost full, your patient will need to follow local community guidelines for the right way to dispose of the sharps disposal container. There may be state or local laws about how your patient should throw away used needles and syringes. For more information about safe sharps disposal and for specific information about sharps disposal in the state that your patient lives in, they can visit the FDA’s website at FDA.gov/safesharpsdisposal.
Your patient must not dispose of used sharps disposal container in the household trash unless local community guidelines permit this. Your patient must not recycle the used sharps disposal container.